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Neuroscience

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JoVE Journal Neuroscience
A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Article DOI: 10.3791/56569-v • 07:02 min • February 11th, 2019
February 11th, 2019 •
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1Centre for Human Drug Research (CHDR), Leiden

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A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.

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Computerized Test Battery Pharmacodynamic Effects Central Nervous System Cholinergic Drugs Early Phase Drug Development Neuropsychological Methods Neurophysiological Methods Concentration Effects Relationships Dose Escalation Decisions Test Battery Computer Computer Screen Joystick Preferred Hand Test Script Subject And Study Number Test Assistance Screen Performance Monitoring Difficulty Factor Two Outer Canthus Of The Right Eye
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